Can help relax blood vessels, supporting sexual function, vascular health, and healthy aging.
Why Tadalafil
A study of over 29,000 men found tadalafil users had a 44% lower risk of dying from any cause compared to non-users. Groups were matched for blood pressure, diabetes, and cholesterol medications.
Source: Kloner et al., "The Association of Tadalafil Exposure With Lower Rates of Major Adverse Cardiovascular Events and Mortality," Clinical Cardiology (2024)
Tadalafil users had 19% fewer major cardiovascular events — including heart attacks, strokes, and heart failure — and a 55% lower risk of dying from a cardiovascular cause.
Source: Kloner et al., "The Association of Tadalafil Exposure With Lower Rates of Major Adverse Cardiovascular Events and Mortality," Clinical Cardiology (2024)
A separate study of over 72,000 men found PDE-5 inhibitor users had 25% lower overall mortality and 13% fewer major heart events than non-users.
Source: Kloner et al., Journal of Sexual Medicine (2023) & Andersson et al., Journal of the American College of Cardiology (2021)
Tadalafil mechanism of action
Tadalafil works on one enzyme in your vascular system. This single action supports vascular health, sexual function, and longevity.
Step 1
Tadalafil inhibits PDE5, the enzyme that breaks down cGMP, the chemical signal that keeps blood vessels relaxed.
Step 2
cGMP can then stay active longer. This helps blood vessels stay relaxed which can help keep circulation running smoothly.
Step 3
This vasodilation effect has been shown to help support sexual function (the FDA-approved use). But the same effect works throughout your vascular system. Daily low-dose use may also support cardiovascular and endothelial health.
About Tadalafil
Tadalafil
More than a sexual health medication — Tadalafil can enhance blood flow and vascular health, foundational to supporting longevity.
Metformin
Can improve insulin sensitivity, which helps reduce chronic metabolic stress.
Acarbose
Can slow carbohydrate digestion, flattening blood sugar spikes that may drive hunger and fat storage.
Estradiol
Low-dose local estrogen that can help reverse the vaginal and urinary changes of menopause.
Minoxidil
A clinically-backed treatment, often prescribed off-label for hair regrowth.
Tretinoin
A topical cream shown in large-scale studies to help rebuild collagen and strengthen skin.
Answer a few quick questions and we'll match you with the best option for your goals. A physician reviews every recommendation, and there is no charge until your prescription is approved.
Get a Recommendation