Immortals Medicine
AccountGet a Recommendation
Tadalafil (Generic for Cialis®)
Support longevityBetter sex

Tadalafil (Generic for Cialis®)

Can help relax blood vessels, supporting sexual function, vascular health, and healthy aging.

From $360.00/mo

Billed monthly.

Get Started

Not sure? Take the quiz

“Tadalafil enhances my endothelial function, reduces my inflammation markers, and potentially protects me against age-related cardiovascular and metabolic decline.”

Bryan Johnson
– Bryan Johnson

Why Tadalafil

Blood vessels tighten as you age. Tadalafil helps keep them open.

Get Started
With tadalafil
Without tadalafil

A study of over 29,000 men found tadalafil users had a 44% lower risk of dying from any cause compared to non-users. Groups were matched for blood pressure, diabetes, and cholesterol medications.

Source: Kloner et al., "The Association of Tadalafil Exposure With Lower Rates of Major Adverse Cardiovascular Events and Mortality," Clinical Cardiology (2024)

Tadalafil users had 19% fewer major cardiovascular events — including heart attacks, strokes, and heart failure — and a 55% lower risk of dying from a cardiovascular cause.

Source: Kloner et al., "The Association of Tadalafil Exposure With Lower Rates of Major Adverse Cardiovascular Events and Mortality," Clinical Cardiology (2024)

A separate study of over 72,000 men found PDE-5 inhibitor users had 25% lower overall mortality and 13% fewer major heart events than non-users.

Source: Kloner et al., Journal of Sexual Medicine (2023) & Andersson et al., Journal of the American College of Cardiology (2021)

TADALAFIL MECHANISM OF ACTION

Opens blood vessels. Supports circulation.

Tadalafil works on one enzyme in your vascular system. This single action supports vascular health, sexual function, and longevity.

Step 1

PDE5 inhibited

Tadalafil inhibits PDE5, the enzyme that breaks down cGMP, the chemical signal that keeps blood vessels relaxed.

Step 2

cGMP preserved

cGMP can then stay active longer. This helps blood vessels stay relaxed which can help keep circulation running smoothly.

Step 3

Vascular function supported

This vasodilation effect has been shown to help support sexual function (the FDA-approved use). But the same effect works throughout your vascular system. Daily low-dose use may also support cardiovascular and endothelial health.

Get Started

ABOUT TADALAFIL

What to know

Daily Cialis®

Keep exploring longevity.

Daily Tadalafil (Generic for Cialis®)

Daily Tadalafil (Generic for Cialis®)

FDA-approved for ED

From $24.00/mo$40.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Acarbose

Acarbose

FDA-approved for type 2 diabetes

From $25.00/mo$40.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Estradiol (Generic for Estrace®)

Estradiol (Generic for Estrace®)

FDA-approved for menopausal symptoms

From $26.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Metformin

Metformin

FDA-approved for type 2 diabetes

From $20.00/mo$35.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Oral Minoxidil

Oral Minoxidil

May support hair growth

From $13.33/mo$30.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Tretinoin

Tretinoin

FDA-approved to treat photoaging

From $25.00/mo$45.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Sermorelin (Injections)

Sermorelin (Injections)

Personalized peptide for growth hormone support

From $118.93/mo$165.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Arousal Peptide (Nasal Spray)

Arousal Peptide (Nasal Spray)

Formulated with bremelanotide to support libido

From $151.20/mo$210.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More

Not sure where to start?

Answer a few quick questions and we'll match you with the best option for your goals. A physician reviews every recommendation, and there is no charge until your prescription is approved.

Get a Recommendation

This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program

Explore

  • Explore Blueprint
  • Explore Biomarkers
  • Help Center
  • Careers
  • Accessibility

Follow us

Immortals Socials

InstagramTikTok

Bryan Johnson Socials

XYouTubeTikTokInstagram
Copyright © 2026 Immortals Medicine|Privacy Policy|Terms of Service

This website is provided for educational and informational purposes only and does not constitute providing medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician.

Tadalafil (Generic for Cialis®)
Support longevityBetter sex

Tadalafil (Generic for Cialis®)

Can help relax blood vessels, supporting sexual function, vascular health, and healthy aging.

From $360.00/mo

Billed monthly.

Get Started

Not sure? Take the quiz

“Tadalafil enhances my endothelial function, reduces my inflammation markers, and potentially protects me against age-related cardiovascular and metabolic decline.”

Bryan Johnson
– Bryan Johnson

Why Tadalafil

Blood vessels tighten as you age. Tadalafil helps keep them open.

Get Started
With tadalafil
Without tadalafil

A study of over 29,000 men found tadalafil users had a 44% lower risk of dying from any cause compared to non-users. Groups were matched for blood pressure, diabetes, and cholesterol medications.

Source: Kloner et al., "The Association of Tadalafil Exposure With Lower Rates of Major Adverse Cardiovascular Events and Mortality," Clinical Cardiology (2024)

Tadalafil users had 19% fewer major cardiovascular events — including heart attacks, strokes, and heart failure — and a 55% lower risk of dying from a cardiovascular cause.

Source: Kloner et al., "The Association of Tadalafil Exposure With Lower Rates of Major Adverse Cardiovascular Events and Mortality," Clinical Cardiology (2024)

A separate study of over 72,000 men found PDE-5 inhibitor users had 25% lower overall mortality and 13% fewer major heart events than non-users.

Source: Kloner et al., Journal of Sexual Medicine (2023) & Andersson et al., Journal of the American College of Cardiology (2021)

TADALAFIL MECHANISM OF ACTION

Opens blood vessels. Supports circulation.

Tadalafil works on one enzyme in your vascular system. This single action supports vascular health, sexual function, and longevity.

Step 1

PDE5 inhibited

Tadalafil inhibits PDE5, the enzyme that breaks down cGMP, the chemical signal that keeps blood vessels relaxed.

Step 2

cGMP preserved

cGMP can then stay active longer. This helps blood vessels stay relaxed which can help keep circulation running smoothly.

Step 3

Vascular function supported

This vasodilation effect has been shown to help support sexual function (the FDA-approved use). But the same effect works throughout your vascular system. Daily low-dose use may also support cardiovascular and endothelial health.

Get Started

ABOUT TADALAFIL

What to know

Daily Cialis®

Keep exploring longevity.

Daily Tadalafil (Generic for Cialis®)

Daily Tadalafil (Generic for Cialis®)

FDA-approved for ED

From $24.00/mo$40.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Acarbose

Acarbose

FDA-approved for type 2 diabetes

From $25.00/mo$40.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Estradiol (Generic for Estrace®)

Estradiol (Generic for Estrace®)

FDA-approved for menopausal symptoms

From $26.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Metformin

Metformin

FDA-approved for type 2 diabetes

From $20.00/mo$35.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Oral Minoxidil

Oral Minoxidil

May support hair growth

From $13.33/mo$30.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Tretinoin

Tretinoin

FDA-approved to treat photoaging

From $25.00/mo$45.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Sermorelin (Injections)

Sermorelin (Injections)

Personalized peptide for growth hormone support

From $118.93/mo$165.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Arousal Peptide (Nasal Spray)

Arousal Peptide (Nasal Spray)

Formulated with bremelanotide to support libido

From $151.20/mo$210.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More

Not sure where to start?

Answer a few quick questions and we'll match you with the best option for your goals. A physician reviews every recommendation, and there is no charge until your prescription is approved.

Get a Recommendation

This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program