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  3. Women's Skin Complex (4-in-1)
Women’s Skin Complex (4-in-1)

“I reversed my skin age by the equivalent of 9 years. Effectively freezing my skin aging over the past five years. Tretinoin is a core part of my skincare protocol.”

Bryan Johnson
– Bryan Johnson
Renew skin

Women’s Skin Complex(4-in-1)

From $64.53/mo$95/mo

A 4-in-1 topical cream combining estriol, finasteride, tretinoin, and niacinamide to target visible signs of aging.

HSA/FSA reimbursable
Founded by Bryan Johnson
No insurance required
Fast, discreet shipping
Licensed US pharmacies
Unlimited follow-up with licensed physicians
HSA/FSA reimbursable
No insurance required
Licensed US pharmacies
Founded by Bryan Johnson
Fast, discreet shipping
Unlimited follow-up with licensed physicians

$0

Membership fees

Get Started

Not sure? Take the quiz

“I reversed my skin age by the equivalent of 9 years. Effectively freezing my skin aging over the past five years. Tretinoin is a core part of my skincare protocol.”

Bryan Johnson
– Bryan Johnson

Why Tretinoin

Increases skin cell turnover. Improves photoaged skin.

With tretinoin
Without tretinoin

Supports sun-damaged skin

In a 6-month trial of nearly 300 adults with sun-damaged skin, 68% using tretinoin showed overall skin improvement.

Source: Olsen et al., "Tretinoin Emollient Cream: A New Therapy for Photodamaged Skin," Journal of the American Academy of Dermatology (1992) & Stern, "Treatment of Photoaging," New England Journal of Medicine (2004)


Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of the referenced medication. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes or expected results.

Get Started

HOW WOMEN’S SKIN COMPLEX WORKS

Rebuilds collagen. Improves skin texture.

Tretinoin switches on genes responsible for producing collagen and regulating pigmentation. Niacinamide evens tone at the surface. Estriol hydrates the skin and increases elasticity. Finasteride blocks DHT, minimizing unwanted facial hair.

connector
connector
connector

Accelerates cell turnover

Dead skin cells shed faster. New cells reach the surface more quickly, improving texture and tone.

Stimulates collagen production

Fibroblasts are activated to produce new collagen, partially reversing structural damage from UV exposure.

Women's Skin Complex (4-in-1)

Strengthens and restores skin

Estriol supports hydration and elasticity, while niacinamide strengthens the skin barrier, reduces redness, and brightens tone.

Women's Skin Complex (4-in-1)

Accelerates cell turnover

Dead skin cells shed faster. New cells reach the surface more quickly, improving texture and tone.

Stimulates collagen production

Fibroblasts are activated to produce new collagen, partially reversing structural damage from UV exposure.

Strengthens and restores skin

Estriol supports hydration and elasticity, while niacinamide strengthens the skin barrier, reduces redness, and brightens tone.

How Immortals Medicine works

From intake to your door in three to seven days

Get Started

The same prescription framework as Bryan Johnson's medical team.

  1. Person completing a medical intake on their phone
    Step 1

    Medical intake

    Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.

    A few minutes
  2. A physician reviewing a patient intake
    Step 2

    Doctor review

    A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*

    Within 72 hours
  3. A discreet medication package at a doorstep
    Step 3

    Fast shipping

    Approved medications ship directly to your door in discreet packaging.

    2-5 business days
  4. Person messaging their doctor from home
    Step 4

    Unlimited messaging

    Your doctor is available by message any time for additional support. Video consults available.

    Up to 12 months
Get Started

The same prescription framework as Bryan Johnson's medical team.

*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.

Keep exploring longevity.

Personalized Tirzepatide (Injections)

Personalized Tirzepatide (Injections)

Can activate both GLP-1 and GIP receptors, the two gut hormones that signal appetite and satiety.

Get StartedLearn More
Personalized Semaglutide (Injections)

Personalized Semaglutide (Injections)

Can help suppress appetite and slow digestion.

Get StartedLearn More
Zepbound® (Kwikpen®)

Zepbound® (Kwikpen®)

Activates both GLP-1 and GIP receptors, the two gut hormones that signal appetite and satiety.

Get StartedLearn More
Wegovy® (Injections)

Wegovy® (Injections)

Activates GLP-1 receptors, the gut hormone that signals appetite and satiety.

Get StartedLearn More
Wegovy® (Tablets)

Wegovy® (Tablets)

Activates GLP-1 receptors, the gut hormone that signals appetite and satiety.

Get StartedLearn More
Foundayo® (Tablets)

Foundayo® (Tablets)

Activates GLP-1 receptors, the gut hormone that signals appetite and satiety.

Get StartedLearn More
Tirzepatide Microdose (Injections)

Tirzepatide Microdose (Injections)

Activates both GLP-1 and GIP receptors.

Get StartedLearn More
Semaglutide Microdose (Injections)

Semaglutide Microdose (Injections)

Activates the GLP-1 pathway at lower doses.

Get StartedLearn More

Why Immortals Medicine

Precision medicine protocols to support longevity

Proactive care

Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.

Transparent pricing

No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.

Board-certified doctors

Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.

Curated by longevity experts

Every protocol is built by medical experts, based on longevity research from Bryan Johnson's science team.

COMMON QUESTIONS

Questions, answered

Compounded medications are not FDA-approved, and the FDA does not evaluate them for safety, effectiveness, or quality prior to use. This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment.

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This website is provided for educational and informational purposes only and does not constitute providing medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician.

  1. Home
  2. Renew skin
  3. Women's Skin Complex (4-in-1)
Women’s Skin Complex (4-in-1)

“I reversed my skin age by the equivalent of 9 years. Effectively freezing my skin aging over the past five years. Tretinoin is a core part of my skincare protocol.”

Bryan Johnson
– Bryan Johnson
Renew skin

Women’s Skin Complex(4-in-1)

From $64.53/mo$95/mo

A 4-in-1 topical cream combining estriol, finasteride, tretinoin, and niacinamide to target visible signs of aging.

HSA/FSA reimbursable
Founded by Bryan Johnson
No insurance required
Fast, discreet shipping
Licensed US pharmacies
Unlimited follow-up with licensed physicians
HSA/FSA reimbursable
No insurance required
Licensed US pharmacies
Founded by Bryan Johnson
Fast, discreet shipping
Unlimited follow-up with licensed physicians

$0

Membership fees

Get Started

Not sure? Take the quiz

“I reversed my skin age by the equivalent of 9 years. Effectively freezing my skin aging over the past five years. Tretinoin is a core part of my skincare protocol.”

Bryan Johnson
– Bryan Johnson

Why Tretinoin

Increases skin cell turnover. Improves photoaged skin.

With tretinoin
Without tretinoin

Supports sun-damaged skin

In a 6-month trial of nearly 300 adults with sun-damaged skin, 68% using tretinoin showed overall skin improvement.

Source: Olsen et al., "Tretinoin Emollient Cream: A New Therapy for Photodamaged Skin," Journal of the American Academy of Dermatology (1992) & Stern, "Treatment of Photoaging," New England Journal of Medicine (2004)


Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of the referenced medication. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes or expected results.

Get Started

HOW WOMEN’S SKIN COMPLEX WORKS

Rebuilds collagen. Improves skin texture.

Tretinoin switches on genes responsible for producing collagen and regulating pigmentation. Niacinamide evens tone at the surface. Estriol hydrates the skin and increases elasticity. Finasteride blocks DHT, minimizing unwanted facial hair.

connector
connector
connector

Accelerates cell turnover

Dead skin cells shed faster. New cells reach the surface more quickly, improving texture and tone.

Stimulates collagen production

Fibroblasts are activated to produce new collagen, partially reversing structural damage from UV exposure.

Women's Skin Complex (4-in-1)

Strengthens and restores skin

Estriol supports hydration and elasticity, while niacinamide strengthens the skin barrier, reduces redness, and brightens tone.

Women's Skin Complex (4-in-1)

Accelerates cell turnover

Dead skin cells shed faster. New cells reach the surface more quickly, improving texture and tone.

Stimulates collagen production

Fibroblasts are activated to produce new collagen, partially reversing structural damage from UV exposure.

Strengthens and restores skin

Estriol supports hydration and elasticity, while niacinamide strengthens the skin barrier, reduces redness, and brightens tone.

How Immortals Medicine works

From intake to your door in three to seven days

Get Started

The same prescription framework as Bryan Johnson's medical team.

  1. Person completing a medical intake on their phone
    Step 1

    Medical intake

    Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.

    A few minutes
  2. A physician reviewing a patient intake
    Step 2

    Doctor review

    A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*

    Within 72 hours
  3. A discreet medication package at a doorstep
    Step 3

    Fast shipping

    Approved medications ship directly to your door in discreet packaging.

    2-5 business days
  4. Person messaging their doctor from home
    Step 4

    Unlimited messaging

    Your doctor is available by message any time for additional support. Video consults available.

    Up to 12 months
Get Started

The same prescription framework as Bryan Johnson's medical team.

*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.

Keep exploring longevity.

Personalized Tirzepatide (Injections)

Personalized Tirzepatide (Injections)

Can activate both GLP-1 and GIP receptors, the two gut hormones that signal appetite and satiety.

Get StartedLearn More
Personalized Semaglutide (Injections)

Personalized Semaglutide (Injections)

Can help suppress appetite and slow digestion.

Get StartedLearn More
Zepbound® (Kwikpen®)

Zepbound® (Kwikpen®)

Activates both GLP-1 and GIP receptors, the two gut hormones that signal appetite and satiety.

Get StartedLearn More
Wegovy® (Injections)

Wegovy® (Injections)

Activates GLP-1 receptors, the gut hormone that signals appetite and satiety.

Get StartedLearn More
Wegovy® (Tablets)

Wegovy® (Tablets)

Activates GLP-1 receptors, the gut hormone that signals appetite and satiety.

Get StartedLearn More
Foundayo® (Tablets)

Foundayo® (Tablets)

Activates GLP-1 receptors, the gut hormone that signals appetite and satiety.

Get StartedLearn More
Tirzepatide Microdose (Injections)

Tirzepatide Microdose (Injections)

Activates both GLP-1 and GIP receptors.

Get StartedLearn More
Semaglutide Microdose (Injections)

Semaglutide Microdose (Injections)

Activates the GLP-1 pathway at lower doses.

Get StartedLearn More

Why Immortals Medicine

Precision medicine protocols to support longevity

Proactive care

Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.

Transparent pricing

No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.

Board-certified doctors

Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.

Curated by longevity experts

Every protocol is built by medical experts, based on longevity research from Bryan Johnson's science team.

COMMON QUESTIONS

Questions, answered

Compounded medications are not FDA-approved, and the FDA does not evaluate them for safety, effectiveness, or quality prior to use. This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment.