Tirzepatide Microdose (Injections)
Activates both GLP-1 and GIP receptors.
What Bryan takesRenew skin
Tretinoin
From $25/mo$45/mo
Stimulates collagen production, improves skin texture, and reverses photoaging.
HSA/FSA reimbursable
Founded by Bryan Johnson
No insurance required
Fast, discreet shipping
Licensed US pharmacies
Unlimited follow-up with licensed physicians
HSA/FSA reimbursable
No insurance required
Licensed US pharmacies
Founded by Bryan Johnson
Fast, discreet shipping
Unlimited follow-up with licensed physicians
$0
Membership fees
“Tretinoin is the gold-standard topical anti-aging agent, with robust clinical trial evidence demonstrating improvements in fine wrinkling, hyperpigmentation, and collagen synthesis in photodamaged skin. It is a core part of my skincare protocol.”
Why Tretinoin
Increases skin cell turnover. Improves photoaged skin.
With tretinoin
Without tretinoin
Improves overall skin in 68% of users
In a 6-month trial of nearly 300 adults with sun-damaged skin, 68% using tretinoin showed overall skin improvement.
Source: Olsen et al., "Tretinoin Emollient Cream: A New Therapy for Photodamaged Skin," Journal of the American Academy of Dermatology (1992) & Stern, "Treatment of Photoaging," New England Journal of Medicine (2004)
Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of the referenced medication. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes or expected results.
HOW TRETINOIN WORKS
Renews skin cells. Rebuilds collagen.
Tretinoin is the active form of vitamin A. When applied to the skin, it enters cells and activates receptors that influence how skin cells grow, divide, and mature. Over time, this can lead to faster cell turnover, increased collagen production, and smoother, more even-looking skin.
Activates retinoic acid receptors
When applied to the skin, tretinoin enters skin cells and activates genes involved in how skin cells grow, divide, and mature.
Increases collagen production
That same signal prompts cells in the deeper layer of skin (fibroblasts) to produce more collagen — the protein responsible for firmness and resilience.
Boosts skin cell turnover
Tretinoin speeds up the rate at which old skin cells shed, restoring a pace of turnover that naturally slows with age and sun exposure. Over weeks to months, skin texture can smooth out, tone typically becomes more even, and fine lines may become less visible. Improvement is gradual and builds with consistent use.
How Immortals Medicine works
From intake to your door in three to seven days
Step 1Medical intake
Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.
A few minutes
Step 2Doctor review
A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*
Within 72 hours
Step 3Fast shipping
Approved medications ship directly to your door in discreet packaging.
2-5 business days
Step 4Unlimited messaging
Your doctor is available by message any time for additional support. Video consults available.
Up to 12 months
Get Started
The same prescription framework as Bryan Johnson's medical team.
*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.
Keep exploring longevity.
Semaglutide Microdose (Injections)
Activates the GLP-1 pathway at lower doses.
Sermorelin (Injections)
Stimulates the pituitary gland's natural release of growth hormone.
NAD+ (Injections)
Can replenish NAD+ levels, which naturally decline with age.
Glutathione (Injections)
Can help defend cells against oxidative damage.
NAD+ (Nasal Spray)
Can replenish NAD+ levels, which naturally decline with age.
Glutathione (Nasal Spray)
Can help defend cells against oxidative damage.
Peptide Skin Complex (4-in-1)
Helps reduce fine lines, fade dark spots, and brighten skin tone.
Why Immortals Medicine
Precision medicine protocols to support longevity
Proactive care
Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.
Transparent pricing
No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.
Board-certified doctors
Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.
Curated by longevity experts
Every protocol is built by medical experts, based on longevity research from Bryan Johnson's science team.
COMMON QUESTIONS
Questions, answered
This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program