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  2. Explore peptides
  3. Sermorelin (Injections)
Sermorelin

“Sermorelin is a peptide that prompts your body to release its own growth hormone in natural pulses. It works through the same mechanism as tesamorelin, an FDA-approved peptide that's been shown to shrink visceral fat. Sermorelin itself has never been tested in a clinical trial so using it for weight management is experimental and off-label.”

Carl Seger, M.D.
– Dr. Carl Seger M.D.
Lose weightExplore peptides

Sermorelin

From $118.93/mo$165/mo

An experimental peptide protocol. Stimulates the pituitary gland’s natural release of growth hormone. This can support fat loss and muscle gain.

HSA/FSA reimbursable
Founded by Bryan Johnson
No insurance required
Fast, discreet shipping
Licensed US pharmacies
Unlimited follow-up with licensed physicians
HSA/FSA reimbursable
No insurance required
Licensed US pharmacies
Founded by Bryan Johnson
Fast, discreet shipping
Unlimited follow-up with licensed physicians

$0

Membership fees

Get Started

Not sure? Take the quiz

“Sermorelin is a peptide that prompts your body to release its own growth hormone in natural pulses. It works through the same mechanism as tesamorelin, an FDA-approved peptide that's been shown to shrink visceral fat. Sermorelin itself has never been tested in a clinical trial so using it for weight management is experimental and off-label.”

Carl Seger, M.D.
– Dr. Carl Seger M.D.

Why GHRH agonists

Growth hormone declines with age. GHRH agonists help restart the signal.

With GHRH agonist
Without GHRH agonist

Growth hormone slows with age

Growth hormone (GH) production declines ~14% per decade after age 30. The driver is declining GHRH output, not pituitary failure. Because the pituitary remains responsive, reintroducing the GHRH signal can restart GH production.

Source: Melmed S, NEJM (2019); Aimaretti et al., J Endocrinol Invest (2008)


Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of the referenced medication. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes or expected results.

Get Started

HOW SERMORELIN WORKS

Stimulates natural growth hormone release.

Sermorelin prompts your pituitary gland to release growth hormone, supporting muscle growth, fat loss, sleep, and recovery.

connector
connector
connector

Signals pituitary gland

Sermorelin acts on cells in the pituitary gland, mimicking signals your body naturally sends to release growth hormone.

Releases growth hormone

The pituitary releases your body's own growth hormone in its natural rhythm of pulses, the on-off pattern your body is designed to respond to.

Sermorelin (Injections)

Supports metabolism

Growth hormone circulates to the liver, where it stimulates IGF-1 production. They work together to support increased muscle mass, fat loss, sleep, recovery, and tissue repair.

Sermorelin (Injections)

Signals pituitary gland

Sermorelin acts on cells in the pituitary gland, mimicking signals your body naturally sends to release growth hormone.

Releases growth hormone

The pituitary releases your body's own growth hormone in its natural rhythm of pulses, the on-off pattern your body is designed to respond to.

Supports metabolism

Growth hormone circulates to the liver, where it stimulates IGF-1 production. They work together to support increased muscle mass, fat loss, sleep, recovery, and tissue repair.

How Immortals Medicine works

From intake to your door in three to seven days

Get Started

The same prescription framework as Bryan Johnson's medical team.

  1. Person completing a medical intake on their phone
    Step 1

    Medical intake

    Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.

    A few minutes
  2. A physician reviewing a patient intake
    Step 2

    Doctor review

    A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*

    Within 72 hours
  3. A discreet medication package at a doorstep
    Step 3

    Fast shipping

    Approved medications ship directly to your door in discreet packaging.

    2-5 business days
  4. Person messaging their doctor from home
    Step 4

    Unlimited messaging

    Your doctor is available by message any time for additional support. Video consults available.

    Up to 12 months
Get Started

The same prescription framework as Bryan Johnson's medical team.

*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.

Keep exploring longevity.

Personalized Tirzepatide (Injections)

Personalized Tirzepatide (Injections)

Can activate both GLP-1 and GIP receptors, the two gut hormones that signal appetite and satiety.

Get StartedLearn More
Personalized Semaglutide (Injections)

Personalized Semaglutide (Injections)

Can help suppress appetite and slow digestion.

Get StartedLearn More
Zepbound® (Kwikpen®)

Zepbound® (Kwikpen®)

Activates both GLP-1 and GIP receptors, the two gut hormones that signal appetite and satiety.

Get StartedLearn More
Wegovy® (Injections)

Wegovy® (Injections)

Activates GLP-1 receptors, the gut hormone that signals appetite and satiety.

Get StartedLearn More
Wegovy® (Tablets)

Wegovy® (Tablets)

Activates GLP-1 receptors, the gut hormone that signals appetite and satiety.

Get StartedLearn More
Foundayo® (Tablets)

Foundayo® (Tablets)

Activates GLP-1 receptors, the gut hormone that signals appetite and satiety.

Get StartedLearn More
Tirzepatide Microdose (Injections)

Tirzepatide Microdose (Injections)

Activates both GLP-1 and GIP receptors.

Get StartedLearn More
Semaglutide Microdose (Injections)

Semaglutide Microdose (Injections)

Activates the GLP-1 pathway at lower doses.

Get StartedLearn More

Why Immortals Medicine

Precision medicine protocols to support longevity

Proactive care

Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.

Transparent pricing

No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.

Board-certified doctors

Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.

Curated by longevity experts

Every protocol is built by medical experts, based on longevity research from Bryan Johnson's science team.

COMMON QUESTIONS

Questions, answered

Compounded medications are not FDA-approved, and the FDA does not evaluate them for safety, effectiveness, or quality prior to use. This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment.

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This website is provided for educational and informational purposes only and does not constitute providing medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician.

  1. Home
  2. Explore peptides
  3. Sermorelin (Injections)
Sermorelin

“Sermorelin is a peptide that prompts your body to release its own growth hormone in natural pulses. It works through the same mechanism as tesamorelin, an FDA-approved peptide that's been shown to shrink visceral fat. Sermorelin itself has never been tested in a clinical trial so using it for weight management is experimental and off-label.”

Carl Seger, M.D.
– Dr. Carl Seger M.D.
Lose weightExplore peptides

Sermorelin

From $118.93/mo$165/mo

An experimental peptide protocol. Stimulates the pituitary gland’s natural release of growth hormone. This can support fat loss and muscle gain.

HSA/FSA reimbursable
Founded by Bryan Johnson
No insurance required
Fast, discreet shipping
Licensed US pharmacies
Unlimited follow-up with licensed physicians
HSA/FSA reimbursable
No insurance required
Licensed US pharmacies
Founded by Bryan Johnson
Fast, discreet shipping
Unlimited follow-up with licensed physicians

$0

Membership fees

Get Started

Not sure? Take the quiz

“Sermorelin is a peptide that prompts your body to release its own growth hormone in natural pulses. It works through the same mechanism as tesamorelin, an FDA-approved peptide that's been shown to shrink visceral fat. Sermorelin itself has never been tested in a clinical trial so using it for weight management is experimental and off-label.”

Carl Seger, M.D.
– Dr. Carl Seger M.D.

Why GHRH agonists

Growth hormone declines with age. GHRH agonists help restart the signal.

With GHRH agonist
Without GHRH agonist

Growth hormone slows with age

Growth hormone (GH) production declines ~14% per decade after age 30. The driver is declining GHRH output, not pituitary failure. Because the pituitary remains responsive, reintroducing the GHRH signal can restart GH production.

Source: Melmed S, NEJM (2019); Aimaretti et al., J Endocrinol Invest (2008)


Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of the referenced medication. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes or expected results.

Get Started

HOW SERMORELIN WORKS

Stimulates natural growth hormone release.

Sermorelin prompts your pituitary gland to release growth hormone, supporting muscle growth, fat loss, sleep, and recovery.

connector
connector
connector

Signals pituitary gland

Sermorelin acts on cells in the pituitary gland, mimicking signals your body naturally sends to release growth hormone.

Releases growth hormone

The pituitary releases your body's own growth hormone in its natural rhythm of pulses, the on-off pattern your body is designed to respond to.

Sermorelin (Injections)

Supports metabolism

Growth hormone circulates to the liver, where it stimulates IGF-1 production. They work together to support increased muscle mass, fat loss, sleep, recovery, and tissue repair.

Sermorelin (Injections)

Signals pituitary gland

Sermorelin acts on cells in the pituitary gland, mimicking signals your body naturally sends to release growth hormone.

Releases growth hormone

The pituitary releases your body's own growth hormone in its natural rhythm of pulses, the on-off pattern your body is designed to respond to.

Supports metabolism

Growth hormone circulates to the liver, where it stimulates IGF-1 production. They work together to support increased muscle mass, fat loss, sleep, recovery, and tissue repair.

How Immortals Medicine works

From intake to your door in three to seven days

Get Started

The same prescription framework as Bryan Johnson's medical team.

  1. Person completing a medical intake on their phone
    Step 1

    Medical intake

    Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.

    A few minutes
  2. A physician reviewing a patient intake
    Step 2

    Doctor review

    A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*

    Within 72 hours
  3. A discreet medication package at a doorstep
    Step 3

    Fast shipping

    Approved medications ship directly to your door in discreet packaging.

    2-5 business days
  4. Person messaging their doctor from home
    Step 4

    Unlimited messaging

    Your doctor is available by message any time for additional support. Video consults available.

    Up to 12 months
Get Started

The same prescription framework as Bryan Johnson's medical team.

*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.

Keep exploring longevity.

Personalized Tirzepatide (Injections)

Personalized Tirzepatide (Injections)

Can activate both GLP-1 and GIP receptors, the two gut hormones that signal appetite and satiety.

Get StartedLearn More
Personalized Semaglutide (Injections)

Personalized Semaglutide (Injections)

Can help suppress appetite and slow digestion.

Get StartedLearn More
Zepbound® (Kwikpen®)

Zepbound® (Kwikpen®)

Activates both GLP-1 and GIP receptors, the two gut hormones that signal appetite and satiety.

Get StartedLearn More
Wegovy® (Injections)

Wegovy® (Injections)

Activates GLP-1 receptors, the gut hormone that signals appetite and satiety.

Get StartedLearn More
Wegovy® (Tablets)

Wegovy® (Tablets)

Activates GLP-1 receptors, the gut hormone that signals appetite and satiety.

Get StartedLearn More
Foundayo® (Tablets)

Foundayo® (Tablets)

Activates GLP-1 receptors, the gut hormone that signals appetite and satiety.

Get StartedLearn More
Tirzepatide Microdose (Injections)

Tirzepatide Microdose (Injections)

Activates both GLP-1 and GIP receptors.

Get StartedLearn More
Semaglutide Microdose (Injections)

Semaglutide Microdose (Injections)

Activates the GLP-1 pathway at lower doses.

Get StartedLearn More

Why Immortals Medicine

Precision medicine protocols to support longevity

Proactive care

Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.

Transparent pricing

No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.

Board-certified doctors

Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.

Curated by longevity experts

Every protocol is built by medical experts, based on longevity research from Bryan Johnson's science team.

COMMON QUESTIONS

Questions, answered

Compounded medications are not FDA-approved, and the FDA does not evaluate them for safety, effectiveness, or quality prior to use. This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment.