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Peptide Skin Complex (4-in-1)
Renew skinExplore peptides

Peptide Skin Complex (4-in-1)

A 4-in-1 topical cream including tretinoin, caffeine, GHK-Cu, and niacinamide. Helps reduce fine lines, fade dark spots, rebuild collagen, and brighten skin tone.

From $133.33/mo$185.00/mo

Billed quarterly with a three-month commitment paid up front.

Get Started

Not sure? Take the quiz

“I reversed my skin age by the equivalent of 9 years. Effectively freezing my skin aging over the past five years. Tretinoin is a core part of my skincare protocol.”

Bryan Johnson
– Bryan Johnson

Why Tretinoin

Increases skin cell turnover. Improves photoaged skin.

Get Started
With tretinoin
Without tretinoin

In a 6-month trial of nearly 300 adults with sun-damaged skin, 68% using tretinoin showed overall skin improvement.

Source: Olsen et al., "Tretinoin Emollient Cream: A New Therapy for Photodamaged Skin," Journal of the American Academy of Dermatology (1992) & Stern, "Treatment of Photoaging," New England Journal of Medicine (2004)

The trial found tretinoin was effective at reducing fine wrinkles, uneven brown spots (mottled hyperpigmentation), and rough skin texture.

Source: Olsen et al., "Tretinoin Emollient Cream: A New Therapy for Photodamaged Skin," Journal of the American Academy of Dermatology (1992) & Stern, "Treatment of Photoaging," New England Journal of Medicine (2004)

Across multiple similar trials, the rate of improvement with tretinoin was roughly double that of placebo.

Source: Olsen et al., "Tretinoin Emollient Cream: A New Therapy for Photodamaged Skin," Journal of the American Academy of Dermatology (1992) & Stern, "Treatment of Photoaging," New England Journal of Medicine (2004)

PEPTIDE SKIN COMPLEX MECHANISM OF ACTION

Rebuilds skin at every layer.

Tretinoin stimulates collagen production and reduces pigmentation, caffeine provides antioxidant defense. GHK-Cu can improve skin elasticity. Niacinamide may even skin tone at the surface.

Step 1

Accelerates skin cell turnover

Dead skin cells shed faster. New cells reach the surface more quickly, improving texture and tone.

Step 2

Stimulates collagen production

Fibroblasts are activated, producing new collagen, and helping reverse structural damage from UV exposure.

Step 3

Improves complexion

Can reduce melanin production, and redness, fading dark spots and brightening out skin tone.

Get Started

ABOUT PEPTIDE SKIN COMPLEX

What to know

Peptide Skin Complex (4-in-1)

Keep exploring longevity.

Tretinoin

Tretinoin

FDA-approved to treat photoaging

From $25.00/mo$45.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Women's Skin Complex (4-in-1)

Women's Skin Complex (4-in-1)

Anti-aging topical with tretinoin, estriol, finasteride, and niacinamide

From $64.53/mo$95.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Acarbose

Acarbose

FDA-approved for type 2 diabetes

From $25.00/mo$40.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Estradiol (Generic for Estrace®)

Estradiol (Generic for Estrace®)

FDA-approved for menopausal symptoms

From $26.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Metformin

Metformin

FDA-approved for type 2 diabetes

From $20.00/mo$35.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Oral Minoxidil

Oral Minoxidil

May support hair growth

From $13.33/mo$30.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Daily Tadalafil (Generic for Cialis®)

Daily Tadalafil (Generic for Cialis®)

FDA-approved for ED

From $24.00/mo$40.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Sermorelin (Injections)

Sermorelin (Injections)

Personalized peptide for growth hormone support

From $118.93/mo$165.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More

Not sure where to start?

Answer a few quick questions and we'll match you with the best option for your goals. A physician reviews every recommendation, and there is no charge until your prescription is approved.

Get a Recommendation

Compounded medications are not FDA-approved, and the FDA does not evaluate them for safety, effectiveness, or quality prior to use. This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment.

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This website is provided for educational and informational purposes only and does not constitute providing medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician.

Peptide Skin Complex (4-in-1)
Renew skinExplore peptides

Peptide Skin Complex (4-in-1)

A 4-in-1 topical cream including tretinoin, caffeine, GHK-Cu, and niacinamide. Helps reduce fine lines, fade dark spots, rebuild collagen, and brighten skin tone.

From $133.33/mo$185.00/mo

Billed quarterly with a three-month commitment paid up front.

Get Started

Not sure? Take the quiz

“I reversed my skin age by the equivalent of 9 years. Effectively freezing my skin aging over the past five years. Tretinoin is a core part of my skincare protocol.”

Bryan Johnson
– Bryan Johnson

Why Tretinoin

Increases skin cell turnover. Improves photoaged skin.

Get Started
With tretinoin
Without tretinoin

In a 6-month trial of nearly 300 adults with sun-damaged skin, 68% using tretinoin showed overall skin improvement.

Source: Olsen et al., "Tretinoin Emollient Cream: A New Therapy for Photodamaged Skin," Journal of the American Academy of Dermatology (1992) & Stern, "Treatment of Photoaging," New England Journal of Medicine (2004)

The trial found tretinoin was effective at reducing fine wrinkles, uneven brown spots (mottled hyperpigmentation), and rough skin texture.

Source: Olsen et al., "Tretinoin Emollient Cream: A New Therapy for Photodamaged Skin," Journal of the American Academy of Dermatology (1992) & Stern, "Treatment of Photoaging," New England Journal of Medicine (2004)

Across multiple similar trials, the rate of improvement with tretinoin was roughly double that of placebo.

Source: Olsen et al., "Tretinoin Emollient Cream: A New Therapy for Photodamaged Skin," Journal of the American Academy of Dermatology (1992) & Stern, "Treatment of Photoaging," New England Journal of Medicine (2004)

PEPTIDE SKIN COMPLEX MECHANISM OF ACTION

Rebuilds skin at every layer.

Tretinoin stimulates collagen production and reduces pigmentation, caffeine provides antioxidant defense. GHK-Cu can improve skin elasticity. Niacinamide may even skin tone at the surface.

Step 1

Accelerates skin cell turnover

Dead skin cells shed faster. New cells reach the surface more quickly, improving texture and tone.

Step 2

Stimulates collagen production

Fibroblasts are activated, producing new collagen, and helping reverse structural damage from UV exposure.

Step 3

Improves complexion

Can reduce melanin production, and redness, fading dark spots and brightening out skin tone.

Get Started

ABOUT PEPTIDE SKIN COMPLEX

What to know

Peptide Skin Complex (4-in-1)

Keep exploring longevity.

Tretinoin

Tretinoin

FDA-approved to treat photoaging

From $25.00/mo$45.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Women's Skin Complex (4-in-1)

Women's Skin Complex (4-in-1)

Anti-aging topical with tretinoin, estriol, finasteride, and niacinamide

From $64.53/mo$95.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Acarbose

Acarbose

FDA-approved for type 2 diabetes

From $25.00/mo$40.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Estradiol (Generic for Estrace®)

Estradiol (Generic for Estrace®)

FDA-approved for menopausal symptoms

From $26.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Metformin

Metformin

FDA-approved for type 2 diabetes

From $20.00/mo$35.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Oral Minoxidil

Oral Minoxidil

May support hair growth

From $13.33/mo$30.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Daily Tadalafil (Generic for Cialis®)

Daily Tadalafil (Generic for Cialis®)

FDA-approved for ED

From $24.00/mo$40.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More
Sermorelin (Injections)

Sermorelin (Injections)

Personalized peptide for growth hormone support

From $118.93/mo$165.00/mo

Billed quarterly with a three-month commitment paid up front.

Get StartedLearn More

Not sure where to start?

Answer a few quick questions and we'll match you with the best option for your goals. A physician reviews every recommendation, and there is no charge until your prescription is approved.

Get a Recommendation

Compounded medications are not FDA-approved, and the FDA does not evaluate them for safety, effectiveness, or quality prior to use. This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment.