Tirzepatide Microdose (Injections)
Activates both GLP-1 and GIP receptors.
Support longevitySupport weight loss
Metformin
From $20/mo$35/mo
Activates AMPK, the body's cellular energy switch, supporting steadier blood sugar, metabolic health, and longevity.
HSA/FSA reimbursable
Founded by Bryan Johnson
No insurance required
Fast, discreet shipping
Licensed US pharmacies
Unlimited follow-up with licensed physicians
HSA/FSA reimbursable
No insurance required
Licensed US pharmacies
Founded by Bryan Johnson
Fast, discreet shipping
Unlimited follow-up with licensed physicians
$0
Membership fees
“I've taken metformin for years as part of my longevity stack. It activates AMPK — a cellular energy sensor that mimics some effects of caloric restriction — and has anti-inflammatory properties supported by decades of observational data. I cycle it in 6-week intervals to avoid any potential interference with exercise-driven adaptations.”
Why Metformin
Metformin may target pathways linked to biological aging.
GPD1 pathway biology
Typical biology
Reduces biological age
In a study of over 300,000 people, metformin users had a biological age 0.36 years younger than non-users — measured by PhenoAge, a blood-based marker of how fast the body is aging internally.
Source: Luo et al., "Effects of Putative Metformin Targets on Phenotypic Age and Leukocyte Telomere Length," The Lancet Healthy Longevity (2023)
Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of the referenced medication. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes or expected results.
HOW METFORMIN WORKS
Activates AMPK. Mimics fasting.
Metformin works on an energy-sensing pathway in your cells. This can support: blood sugar control, cellular aging, and metabolic health.
Activates AMPK
Metformin activates AMPK, a cellular switch that turns on when energy runs low. When it's on, the body shifts into repair mode, using energy more efficiently and reducing excess glucose production.
Suppresses mTOR
AMPK activation signals the body to dial back mTOR, the pathway that drives cell growth. Keeping mTOR in check is associated with slower cellular aging, and mirrors what the body does during caloric restriction.
Reduces glucose
Metformin can reduce the liver's tendency to release sugar into the bloodstream between meals. The result is steadier blood sugar throughout the day and less strain on insulin production.
How Immortals Medicine works
From intake to your door in three to seven days
Step 1Medical intake
Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.
A few minutes
Step 2Doctor review
A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*
Within 72 hours
Step 3Fast shipping
Approved medications ship directly to your door in discreet packaging.
2-5 business days
Step 4Unlimited messaging
Your doctor is available by message any time for additional support. Video consults available.
Up to 12 months
Get Started
The same prescription framework as Bryan Johnson's medical team.
*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.
Keep exploring longevity.
Semaglutide Microdose (Injections)
Activates the GLP-1 pathway at lower doses.
Sermorelin (Injections)
Stimulates the pituitary gland's natural release of growth hormone.
NAD+ (Injections)
Can replenish NAD+ levels, which naturally decline with age.
Glutathione (Injections)
Can help defend cells against oxidative damage.
NAD+ (Nasal Spray)
Can replenish NAD+ levels, which naturally decline with age.
Glutathione (Nasal Spray)
Can help defend cells against oxidative damage.
Peptide Skin Complex (4-in-1)
Helps reduce fine lines, fade dark spots, and brighten skin tone.
Why Immortals Medicine
Precision medicine protocols to support longevity
Proactive care
Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.
Transparent pricing
No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.
Board-certified doctors
Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.
Curated by longevity experts
Every protocol is built by medical experts, based on longevity research from Bryan Johnson's science team.
COMMON QUESTIONS
Questions, answered
This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program