Can support vaginal tissue as estrogen declines with age.
Why Estradiol
After menopause, vaginal tissue thins and becomes fragile. In a trial of 550 postmenopausal women, low-dose estradiol cream significantly restored tissue health compared to a placebo cream.
Source: Kroll et al., "A Randomized, Multicenter, Double-Blind Study to Evaluate the Safety and Efficacy of Estradiol Vaginal Cream 0.003%," Menopause (2018)
Women also reported real improvements in daily comfort. Pain during intercourse decreased at weeks 8 and 12. Vaginal dryness improved by week 12. Vaginal pH dropped by 1.36 points versus 0.53 with placebo.
Source: Kroll et al., Menopause (2018) & Archer et al., Journal of Women's Health (2018)
At low doses, it has less systemic absorption compared to oral estrogen and no demonstrated increase in risk of breast cancer, heart disease, or blood clots.
Source: Biehl et al., "A Systematic Review of the Efficacy and Safety of Vaginal Estrogen Products," Menopause (2019) & Pinkerton, "Hormone Therapy for Postmenopausal Women," NEJM (2020)
Estradiol mechanism of action
Estradiol works locally on vaginal tissue. This can support tissue health, sexual function, and urinary health.
Step 1
Estradiol cream is applied directly to vaginal tissue. It absorbs locally, with decreased risk of elevating estrogen levels elsewhere in the body.
Step 2
Vaginal, urethral, and bladder tissue absorbs estradiol locally. This can help restore epithelial thickness, moisture, and acidic pH.
Step 3
As acidic pH returns, Lactobacillus can thrive again. This protective bacteria may help ease dryness, painful sex, recurrent UTIs, and incontinence.
About Estradiol
Estradiol
Low-dose local estrogen that can help reverse the vaginal and urinary changes of menopause.
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