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  1. Home
  2. Lose weight
  3. Brenzavvy®
Brenzavvy® (bexagliflozin)

“Bexagliflozin lowers the renal threshold for glucose, routing roughly 280 calories per day of excess glucose into the urine and shifting substrate utilization toward fat oxidation.”

Carl Seger, M.D.
– Carl Seger, MD, Chief Medical Officer
Support longevitySupport weight loss

Brenzavvy®(bexagliflozin)

From $142.80/mo$210/mo

Can help kidneys flush excess glucose, supporting steadier blood sugar, lower insulin levels, and gradual weight loss.

HSA/FSA reimbursable
Founded by Bryan Johnson
No insurance required
Fast, discreet shipping
Licensed US pharmacies
Unlimited follow-up with licensed physicians
HSA/FSA reimbursable
No insurance required
Licensed US pharmacies
Founded by Bryan Johnson
Fast, discreet shipping
Unlimited follow-up with licensed physicians

$0

Membership fees

Get Started

Not sure? Take the quiz

“Bexagliflozin lowers the renal threshold for glucose, routing roughly 280 calories per day of excess glucose into the urine and shifting substrate utilization toward fat oxidation.”

Carl Seger, M.D.
– Carl Seger, MD, Chief Medical Officer

Why Brenzavvy®

Your kidneys reabsorb glucose. Brenzavvy® can reduce that reabsorption.

With Brenzavvy®
Without Brenzavvy®

Can block glucose reabsorption

Brenzavvy blocks SGLT2, a protein that pulls sugar back into the bloodstream. Excess glucose exits through urine instead.

Source: FDA-Approved Prescribing Information for Bexagliflozin (Brenzavvy), 2025


Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of the referenced medication. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes or expected results.

Get Started

HOW BRENZAVVY® WORKS

Kidney support. Glucose control.

Brenzavvy® works on one mechanism in your kidneys with two potential benefits: less glucose reabsorption and steadier blood sugar.

connector
connector
connector

Blocks SGLT2

SGLT2 is a kidney protein that recycles roughly 90% of filtered glucose back into your blood. Brenzavvy® can block it, cutting reabsorption by 30–60%.

Glucose excreted

Once blocked, glucose leaves through your urine instead of being recycled. This can help lower blood sugar levels without requiring insulin.

Brenzavvy®

Metabolic shift

The glucose your body flushes out carries calories with it. Over time, this can support gradual weight loss and may reduce strain on the heart and kidneys.

Brenzavvy®

Blocks SGLT2

SGLT2 is a kidney protein that recycles roughly 90% of filtered glucose back into your blood. Brenzavvy® can block it, cutting reabsorption by 30–60%.

Glucose excreted

Once blocked, glucose leaves through your urine instead of being recycled. This can help lower blood sugar levels without requiring insulin.

Metabolic shift

The glucose your body flushes out carries calories with it. Over time, this can support gradual weight loss and may reduce strain on the heart and kidneys.

How Immortals Medicine works

From intake to your door in three to seven days

Get Started

The same prescription framework as Bryan Johnson's medical team.

  1. Person completing a medical intake on their phone
    Step 1

    Medical intake

    Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.

    A few minutes
  2. A physician reviewing a patient intake
    Step 2

    Doctor review

    A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*

    Within 72 hours
  3. A discreet medication package at a doorstep
    Step 3

    Fast shipping

    Approved medications ship directly to your door in discreet packaging.

    2-5 business days
  4. Person messaging their doctor from home
    Step 4

    Unlimited messaging

    Your doctor is available by message any time for additional support. Video consults available.

    Up to 12 months
Get Started

The same prescription framework as Bryan Johnson's medical team.

*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.

Keep exploring longevity.

Personalized Tirzepatide (Injections)

Personalized Tirzepatide (Injections)

Can activate both GLP-1 and GIP receptors, the two gut hormones that signal appetite and satiety.

Get StartedLearn More
Personalized Semaglutide (Injections)

Personalized Semaglutide (Injections)

Can help suppress appetite and slow digestion.

Get StartedLearn More
Zepbound® (Kwikpen®)

Zepbound® (Kwikpen®)

Activates both GLP-1 and GIP receptors, the two gut hormones that signal appetite and satiety.

Get StartedLearn More
Wegovy® (Injections)

Wegovy® (Injections)

Activates GLP-1 receptors, the gut hormone that signals appetite and satiety.

Get StartedLearn More
Wegovy® (Tablets)

Wegovy® (Tablets)

Activates GLP-1 receptors, the gut hormone that signals appetite and satiety.

Get StartedLearn More
Foundayo® (Tablets)

Foundayo® (Tablets)

Activates GLP-1 receptors, the gut hormone that signals appetite and satiety.

Get StartedLearn More
Tirzepatide Microdose (Injections)

Tirzepatide Microdose (Injections)

Activates both GLP-1 and GIP receptors.

Get StartedLearn More
Semaglutide Microdose (Injections)

Semaglutide Microdose (Injections)

Activates the GLP-1 pathway at lower doses.

Get StartedLearn More

Why Immortals Medicine

Precision medicine protocols to support longevity

Proactive care

Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.

Transparent pricing

No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.

Board-certified doctors

Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.

Curated by longevity experts

Every protocol is built by medical experts, based on longevity research from Bryan Johnson's science team.

COMMON QUESTIONS

Questions, answered

This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program

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This website is provided for educational and informational purposes only and does not constitute providing medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician.

  1. Home
  2. Lose weight
  3. Brenzavvy®
Brenzavvy® (bexagliflozin)

“Bexagliflozin lowers the renal threshold for glucose, routing roughly 280 calories per day of excess glucose into the urine and shifting substrate utilization toward fat oxidation.”

Carl Seger, M.D.
– Carl Seger, MD, Chief Medical Officer
Support longevitySupport weight loss

Brenzavvy®(bexagliflozin)

From $142.80/mo$210/mo

Can help kidneys flush excess glucose, supporting steadier blood sugar, lower insulin levels, and gradual weight loss.

HSA/FSA reimbursable
Founded by Bryan Johnson
No insurance required
Fast, discreet shipping
Licensed US pharmacies
Unlimited follow-up with licensed physicians
HSA/FSA reimbursable
No insurance required
Licensed US pharmacies
Founded by Bryan Johnson
Fast, discreet shipping
Unlimited follow-up with licensed physicians

$0

Membership fees

Get Started

Not sure? Take the quiz

“Bexagliflozin lowers the renal threshold for glucose, routing roughly 280 calories per day of excess glucose into the urine and shifting substrate utilization toward fat oxidation.”

Carl Seger, M.D.
– Carl Seger, MD, Chief Medical Officer

Why Brenzavvy®

Your kidneys reabsorb glucose. Brenzavvy® can reduce that reabsorption.

With Brenzavvy®
Without Brenzavvy®

Can block glucose reabsorption

Brenzavvy blocks SGLT2, a protein that pulls sugar back into the bloodstream. Excess glucose exits through urine instead.

Source: FDA-Approved Prescribing Information for Bexagliflozin (Brenzavvy), 2025


Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of the referenced medication. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes or expected results.

Get Started

HOW BRENZAVVY® WORKS

Kidney support. Glucose control.

Brenzavvy® works on one mechanism in your kidneys with two potential benefits: less glucose reabsorption and steadier blood sugar.

connector
connector
connector

Blocks SGLT2

SGLT2 is a kidney protein that recycles roughly 90% of filtered glucose back into your blood. Brenzavvy® can block it, cutting reabsorption by 30–60%.

Glucose excreted

Once blocked, glucose leaves through your urine instead of being recycled. This can help lower blood sugar levels without requiring insulin.

Brenzavvy®

Metabolic shift

The glucose your body flushes out carries calories with it. Over time, this can support gradual weight loss and may reduce strain on the heart and kidneys.

Brenzavvy®

Blocks SGLT2

SGLT2 is a kidney protein that recycles roughly 90% of filtered glucose back into your blood. Brenzavvy® can block it, cutting reabsorption by 30–60%.

Glucose excreted

Once blocked, glucose leaves through your urine instead of being recycled. This can help lower blood sugar levels without requiring insulin.

Metabolic shift

The glucose your body flushes out carries calories with it. Over time, this can support gradual weight loss and may reduce strain on the heart and kidneys.

How Immortals Medicine works

From intake to your door in three to seven days

Get Started

The same prescription framework as Bryan Johnson's medical team.

  1. Person completing a medical intake on their phone
    Step 1

    Medical intake

    Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.

    A few minutes
  2. A physician reviewing a patient intake
    Step 2

    Doctor review

    A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*

    Within 72 hours
  3. A discreet medication package at a doorstep
    Step 3

    Fast shipping

    Approved medications ship directly to your door in discreet packaging.

    2-5 business days
  4. Person messaging their doctor from home
    Step 4

    Unlimited messaging

    Your doctor is available by message any time for additional support. Video consults available.

    Up to 12 months
Get Started

The same prescription framework as Bryan Johnson's medical team.

*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.

Keep exploring longevity.

Personalized Tirzepatide (Injections)

Personalized Tirzepatide (Injections)

Can activate both GLP-1 and GIP receptors, the two gut hormones that signal appetite and satiety.

Get StartedLearn More
Personalized Semaglutide (Injections)

Personalized Semaglutide (Injections)

Can help suppress appetite and slow digestion.

Get StartedLearn More
Zepbound® (Kwikpen®)

Zepbound® (Kwikpen®)

Activates both GLP-1 and GIP receptors, the two gut hormones that signal appetite and satiety.

Get StartedLearn More
Wegovy® (Injections)

Wegovy® (Injections)

Activates GLP-1 receptors, the gut hormone that signals appetite and satiety.

Get StartedLearn More
Wegovy® (Tablets)

Wegovy® (Tablets)

Activates GLP-1 receptors, the gut hormone that signals appetite and satiety.

Get StartedLearn More
Foundayo® (Tablets)

Foundayo® (Tablets)

Activates GLP-1 receptors, the gut hormone that signals appetite and satiety.

Get StartedLearn More
Tirzepatide Microdose (Injections)

Tirzepatide Microdose (Injections)

Activates both GLP-1 and GIP receptors.

Get StartedLearn More
Semaglutide Microdose (Injections)

Semaglutide Microdose (Injections)

Activates the GLP-1 pathway at lower doses.

Get StartedLearn More

Why Immortals Medicine

Precision medicine protocols to support longevity

Proactive care

Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.

Transparent pricing

No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.

Board-certified doctors

Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.

Curated by longevity experts

Every protocol is built by medical experts, based on longevity research from Bryan Johnson's science team.

COMMON QUESTIONS

Questions, answered

This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program